Abstract: Precise process control is one of the most significant problem and now a day’s decentralized Proportional Integral Derivative (PID) controller have commonly used in industries for MIMO system. Design methodologies of a PID controller for the TITO system with time delay based on the predefined reference model of the systems. To obtain PID controller parameters of TITO system are designed using Ziegler-Nichols, Skogestad-IMC, IMC, direct synthesis and Genetic algorithm. The design methodologies use simplified decoupling method to reduce the interaction of TITO system. The simulation result shows that SIMC/GA is superior as compared to all other methods due to the performance parameters of each transient response for the TITO system.