Abstract: Cyanidation of gold allows to reach up to 70% of the extraction subject to the ratio of the concentrations of cyanide oxygen. The proposed control system is based on the MPC that allows optimizing this process taking into account character of the ore, oxygen content, pH and ORP. The control system is based on the predictive model allows to intensify the process of dissolution of gold, to reduce reagent consumption, to prevent the formation of hydrocyanic acid and to reduce the formation of passivating films on the surface of the gold. To increase operational characteristics and improve the accuracy in addition to the control system can be applied the device of measuring the concentration of gold and the increase of oxygen concentration in solutions.