Abstract: Evidence of the need to use sustainable farming practices oriented towards wide application of microbial products is provided in the study based on the data of the negative effect modern technology has due to anthropogenic environmental impacts. It is established that traditional crop treatment practices using the existing machines decrease biological product effectiveness significantly as compared to laboratory data. A number of factors were studied that can influence microbial viability in biological products used to treat seeds and vegetative plants with the help of the chemical crop protection machines. It was revealed that the processes characterized by cavitation have the greatest negative impact. The specified factors are studied through comparison of conventional and sustainable farming technologies. Recommendations were elaborated for development and improvement of machines used to treat crops with microbial products.