Abstract: The effect of Streptomycin (STMY) drug on the surface and micellar properties of Sodium Dodecylbenzyl Sulphate Surfactant (SDBS) have been investigated by surface tension and conductivity measurements at the temperature range 293-323 K. From these measurements, the Critical Micelle Concentration (CMC) Tmax (maximum surface excess) Amin (minimum surface area per molecule) and γ cmc (surface tension at the CMC) have been determined. Thermodynamic parameters (ΔG°m, ΔH°m, ΔS°m) of the micelle formation were calculated from the temperature dependence on the CMC. The standard Gibbs free energies of adsorption ΔG°ads) were also, evaluated and the results show that all the ΔG°ads values are negative and their magnitudes reveal that micelle formation is less spontaneous than adsorption.