Abstract: In this study has been removed sulfur from heavy naphtha by hydrodesulfurization reaction HDS on catalyst consists NiMo supported on graphene, the experiments were done in fixed bed reactor contain catalyst bed. The experiments were designed by using Taguchi method. The design involved study of effect reaction temperature 523-598° K, space velocity LHSV (3-6) h–1 and hydrogen pressure (1-1.3) MPa while H2/oil 2 ratio was kept contestant at 50 mL/mL. Taguchi method help to results analysis in which the analysis exhibited general trend effect for controllable variables. A mathematical model was got for predicting sulfur content in final product by used Levenberg-Marquardt nonlinear regression.