Abstract: The study assessed the efficacy of power point presentation as an information and communication technology tool on achievement of students in Physics and Mathematics. A lone null hypothesis was tested for the study. A one-group time series research design was adopted for the study using a sample of 86 SS 1 Physics students from two secondary schools. The one-group time series subjects were exposed to power point presentation mode of teaching. Identified extraneous variables which could pose threats to the internal validity of the findings of the study were controlled. The instrument used for data collection was Physics and Mathematics Achievement Test (PMAT). Items of PMAT were adopted from the Physics and Mathematics curricula of senior secondary school class one students. The instrument was trial tested and an internal consistency reliability coefficient of 0.85 and estimate of temporal stability of 0.79 were obtained. The subjects were pretested twice before the experiment and post tested twice after the experiment at 3 weeks interval. The data obtained were analyzed using mean and Standard Deviation (SD) and repeated measure Analysis of Variance (ANOVA) was used to test the lone null hypothesis at 0.05 level of significance. The findings revealed that power point presentation as an ICT tool had significant effect on achievement of students in Physics and Mathematics. It was thus, recommended that curriculum planners and teachers should consider the use of ICT tool as instructional mode in teaching and learning of Physics and Mathematics as well as other science subjects.