Abstract: A new system was designed using a column filled with beads (silica gel) properties to determination Paracetamol (PCT) using a reagent N-Bromosuccinimide (NBS) and methyl orange the reaction is done according to the process of oxidation and reduction the wavelength was determined at λmax 507 nm. It was studied physical and chemical variables of the reaction such as such as the of flow rate and weight beads and study the effect of reaction time of saturated and effect of the reaction coil length. It has been found that the optimal concentration of hydrochloric acid 0.5 mol/L and KBr 2% and the methyl orange concentration 8×10–4 mol/L and NBS 0.05 mol/L and study the volume of methyl orange, the detection limit was (3 readings of blank) where the value was equal to 0.0148 mg/L, the technique has been successfully applied to determination PCT in multiple pharmaceutical samples.