Abstract: The nepheline-containing raw materials is studied. As a result of studies it is suggested that a mixed consisting of anionic and cationic surfactants can be used as a collector for reverse flotation of nepheline. Based on studies micelle formation of anionic surfactants (Soaps of Tall Oils of Deciduous (STOD) and coniferous (STOC) wood) and cationic surfactants (FLON-1) and their mixtures justified the optimal ratio of components in the compositions. The effect of anionic and cationic surfactants and their mixtures on wetting and zeta-potential of mineral surfaces was studied. Laboratory tests were carried out on the flotation machine to determine the optimal conditions for flotation of nepheline-containing raw materials. The composition of the collector mixture, the optimal consumption of reagents has been established. The efficiency is best of the collector in flotation of nepheline ores was a mixed of 80% STOD+20% FLON-1