Abstract: This study involves the preparation of colloidal nanoparticles by laser ablation of the solid target immersed in water. Also, it discusses the effect of the number of laser pulses on the structural and optical properties of the prepared CdO/ZnO/Fe2O3 Nanoparticles (NPs). These colloidal nanoparticles were syntheses by laser ablation of a solid target (Cd/Zn/Fe) in DDW solution by using Nd: YAG (λ = 1064 nm, energy = 200 mJ and number of pulses 200 and 1000). Structure, topography and optical properties of the CdO/ZnO/Fe2O3 NPs have been studied using X-Ray Diffraction (XRD), Field Emission Scanning Electron Microscopes (FE-SEM)and the UV-Vis absorption spectroscopy, respectively.