Abstract: This study aims to create a knowledge structure according to the research for development of Southern Thailand in the past 10 years from 2008-2018. The research data was from 78 Departments of Thai National Research Repository (TNRR) and Thai Library Integrated System (ThaiLIS). Content analysis and classification approach has been applied to this qualitative research. It was found that the knowledge structure consists of 2 domains, 32 classes, 227 concepts and 681 sub-concepts.