Abstract: The aim of the study is to re-engineer the relationship among Strategic Planning (SP), Innovation (INN), Employee Strategic Alignment (ESA) and University Operational Performance (UOP). Survey-based procedures and the self-administrative questionnaire have used to collect data from the university academic staff. The questionnaire was used in five points Likert scale. About 500 questionnaires distributed were 309 valid returned. The findings of the study have investigated the relationship between strategic planning and university operational performance through innovation and employee strategic alignment. The proposed hypothesis have supported in order to consist of all the variables relationships. This study has an essential influence of UAE universities that imply the actual theory of strategic planning for university perspectives that increase the operational performance in the university future familiarity and standard operation. The data were gathered from single respondents which might result in possible response bias sometimes that indicates the limitation. This study outcome has preferred or suggested for implementation for the managerial thinking for future bitterness of the organization.