Abstract: The easiest means of increasing capacity of a cellular network without compromising quality of service is through frequency reuse. However, frequency reuse usually results in certain additive and system-generated cellular types of channel interference (co-channel and adjacent channel). In this study, Particle Swarm Optimization (PSO) algorithm was employed to efficiently manage frequency reuse through a neighbour allocation list in order to reduce co-channel and adjacent channel interference to the barest minimum on a live GSM network. Co-channel interference was completely eliminated while adjacent channel interference was reduced by 55% which has a positive impact on the system performance.