Abstract: The study examined the factors that affected poultry production in the avian flu year in Imo State, Nigeria. In line in fulfilling this objective, a well structured questionnaire complimented with interview schedules was administered to poultry farmers in 3 agricultural zones namely Okigwe, Owerri and Orlu on a 4 month period of monthly scheduled from March to June of year 2006. The result indicated a reduction in poultry production during the avian flu year. Experience, cost of production and educational status of the poultry farmers were significant factors that determined poultry production in the avian flu scare year. It is recommended therefore, that increased education and extension services would help sustain poultry production in the study area.