Abstract: The main purpose of this study is to legislation and adjustments for persons with disabilities in Southern Senatorial District in Cross River State, Nigeria. To achieve the purpose of this study, three hypotheses were formulated. Survey research design was adopted for the study. A sample of two hundred persons with disabilities was randomly selected for the study. The selection was done through the simple random sampling technique. The reliability estimate of the instrument was established through the test-retest reliability method Pearson product correlation analysis and independent t-test were employed were adopted to test the hypotheses at 0.05 level of significance. The result of the analysis reveals that that legislation significantly relates with social and economic adjustment of persons with disabilities. The result also revealed that there is a significant gender difference in the legislation of persons with disabilities.