Abstract: Infertility, one of the reproductive health problems of family, is the inability of a man to impregnate or the inability of a woman to conceive and carry a pregnancy to term. The etiology is mostly linked with women in most traditional African societies but in biomedical sciences have discovered that men also contribute to the rate of infertility. The study explores relevant data to unearth various socio-cultural issues in relation to infertility in Nigeria. Findings show that cultural practices often mix infertility with sexuality. Couples who have failed to impregnate or conceive have been found to exhibit various physco-sexual disorders, which affect their self worth and self esteem. A man feels excessive pressure to perform which affects his ejaculatory ability. The need for infertile couples to move beyond the mind-set that all erotic and intimate activity must inevitably lead to penetrative sex, which is associated with reproduction, is recommended to manage the social and psychological impact of infertility.