Abstract: The generation of the base of physical knowledge in the area of nanotechnologies and nanomaterials on the basis of the formalized representation of the structured physical knowledge in the form of physical efforts will allow to systemize and efficiently use the available data relating to the specified subject area. The developed software complex consisting of the Information Retrieval System, system of the automatic synthesis of the physical operating principle and system of the automatic replenishment of the physical effects database will allow to significantly increase the scope of the physical knowledge that is actively used by performance of various research and development and design works in the area of nanotechnologies and nanomaterials as well as solving the test of forecasting the new nano-engineered systems.