Abstract: This research is designed to take the broad and integrative view as a model of public health study. The case study was conducted in Lampung Province, Indonesia. The method used in this study is analytical networks process for the development of model for the management of malaria. The pathogenesis of the disease under study has a complexity which required an involvement of non health sectors. Various scenarios where the best scenario would be the basis for setting policy of vector-borne disease control. The study shows that the rise of the incidence of malaria was strongly associated to the number of abandoned fishponds in the area of the study. The results of the dynamic systems approach suggests that effective malaria control is to manage the environment in the form of anopheles mosquito by controlling breeding places of mosquitoes, i.e., neglected ponds.