Abstract: The use of Willingness-To-Pay (WTP) to value the benefits of health (care) in monetary terms is increasing. We aimed to estimate willingness-to-pay for health status with different severity level and identify determinant factors on WTP. A cross sectional study was conducted in Shiraz, Iran in March and April 2015. The open-ended method was used to estimate monthly WTP. Multivariate regression analyses using ordinary least squares were applied to examine the effect of scio-demographic factors on WTP. The mean value of private WTP is higher than the mean value of the altruistic WTP in all health status. But in worse health status, the mean value difference became greater that means respondents willing to pay private. The calculation of “mild/severe ratio” showed that increasing in severity of illness, the relative increase in private WTP was higher than altruistic WTP. The finding indicates that the mean of WTP increases at sever health status, therefore, health policy maker should allocate resources toward severe health status.