Abstract: The efficacy and suitability of lectin from mucuna sloanei seeds extracts as a cell receptor signal inducer was tested by its agglutinating ability in human and various blood cells such as goat, cow and chicken. The results showed that the isolated lectin from mucuna sloanei seeds extracts agglutinated human ABO, goat and chicken red blood cells at minimal concentration, 11.5 mg mL 1, but did not agglutinate those of cow. It was also found that the physicochemical properties of the lectin did not affect agglutination by variation of the pH of the medium or affected by temperature. This suggests that the mucuna sloanei plant could be considered a good molecular marker for the study of blood group substances.