Abstract: Congenital tuberculosis is defined as tuberculosis occurring in infants as a result of infection acquired from their mothers. Congenital tuberculosis maynot be rare and it is necessary to look into this condition more seriously. Tsanscutaneous liver biopsy may help to confirm it`s prenatal origin and explain causes of the multi organ involvement. We report a case of congenital tuberculosis diagnosed by liver biopsy in infant with FTT and hepatosplenomegally. A 5 month old male infant developed FTT, fatty diarreha and abdominal distension. He had cough, wheezing and weight loss too. On the physical examination there was hepatosplenomegally, axillary and inguinal lymph node enlargement. All of investigations were negative except percutaneous liver and lymph node biopsy that revealed many acid fast bacilli.