Abstract: In 1990 s, empowerment was introduced as an approach in patient education. This program correlated with improved psychosocial self-efficacy. The concept and practice of self-care/self-efficacy will likely be approached differently by people from different cultures. With regards to these point that empowerment program affected by culture, what results would be by performing this program in Eastern and Asian countries. This present study was intended to determining effect of empowerment program education on Self efficacy in Tabriz university of medical science diabetes education center. In this research after a pilot study for 3 month, the necessary sample size was to be used for 22 patients, but the researchers increase it to 30 patients. Randomized sampling method have been used. The research instrument was selected for this research is the Diabetes Empowerment Scale. The intervention consisted of 6 weekly 1 h group sessions. All the participants was stimulated to exploring, sharing experiences with others and choosing personal solutions. In control group, after giving them the questionnaire, we asked the patients to accomplish it then after 1.5 month, we asked them to accomplish it again. This study show that there is no valuable differences between control and intervention group before educating But after educating empowerment program during 6 weeks, intervention group showed positive changes about all psychosocial self-efficacy scales (p = 0.003) and their subscales.