Abstract: Surgical wound infection is a significant cause of post-operative mortality and morbidity in children especially neonates. The aim of the present study was to determine prospectively the incidence of post-operative wound infections in children and to identify the risk factors associated with the development of wound infection. Despite a large series of literatures in adults, there have been a few reports concerning post-operative wound infections in children. All children undergoing operations on the pediatric surgical service during a 4.5 year period in our cente,r were post-operatively followed for 30 days after surgery for the development of a wound infection. The overal incidence of wound infections among 974 children who had undergone the operation was 3.9%. Factors found to be significantly associated with a post-operative wound infection were age of patient (p<0.05) and the amount of contamination during the operation time (p<0.05). There was no significant difference in sex and season of operation. The result of this study demonstrated that wound infection in children is similar to adults, however, in neonates, it is more than adults that is related to the physiologic status.