Abstract: Colorectal cancer is the third most common cancer in the world and the second most common cause of cancer related death. Cox-2 has been reported to be significantly increased in up to 85% of human sporadic colorectal carcinoma. Little is known about interaction between Cox-2 and inflammatory cells of colorectal carcinoma. In all cases, archival H and E slides of the primary tumor were retrieved and reviewed to confirm pathological facture and to select suitable tissue blocks for Immunohistochemical analysis. The expression of Cox-2 was positive (grade 3-7) in 71.3% of tumors and associated with neutrophils, eosinophil, mast cell, macrophages and CD3+ lymphocytes (p = 0.001). Correlation of Cox-2 expression and CD8 lymphocytes was not significant (p = 0.569). The main purpose of this study was to evaluate the interaction between the Cox-2 expression and inflammatory cells. We showed that there is a close relationship of Cox-2 expression and mast cells, neutrophils, eosinophils, macrophages, lymphocyte (CD3+). The only exception was CD8 positive lymphocytes.