Abstract: > Disc protrusion is a very common disorder and usually responds to conservative treatment, but in some patients surgical interventions are inevitable. Percutaneous Laser Disc Decompression (PLDD) is an interventional procedure replacing surgery in some cases of disk protrusion. This study was conducted to evaluate the results of CT guided PLDD. PLDD was performed on 40 patients, who didn't respond to conservative therapies for protrusion. The intervention was carried as an out patient therapy and patients were followed for one year. One week after PLDD, 32 patients (80%) were satisfied with the intervention. At 1, 6 and 12 months follow ups; 31 patients (77%), 30 (75%) and 28 (70%) were satisfied, respectively. No significant complication occurred during the procedure. CT guided PLDD is a useful therapeutic modality in patients suffering disc protrusion which don't respond to conservative treatment.