Abstract: Drought stress causes oxidative damages in plant cells. Two of compounds which have antioxidative characteristic are Salicylic Acid (SA) and Ascorbic acid (As). These compounds can decrease drought effects in plants under stress. In this research, the drought stress was treated in 3 levels of drain (Control, 1/3 Field Capacity, 2/3 Field Capacity). Then, interaction effects of drought stress with SA and As on some of physiological and biochemical parameters of hibiscus esculents L plants were investigated. In recent research, we evaluated parameters such as; leaf area, Dry and Fresh Weight of leaf (DW and FW), lipid per oxidation amount, proline content, sugar content, ion leakage, protein content and photosynthetic pigments content. The results shown that leaf area, FW and DW parameters decreased compared to check under stress significantly. Lipid per oxidation, sugar and proline content and ion leakage increased in plants were under with drought stress. Reduction of protein content in this condition showed that drought stress effected protein biosynthesis and degradation. Moreover, significantly reduction of photosynthetic pigments content showed that stress effected photosynthetic process. Based on our results it seems that salicylic and ascorbic acid can considerably alleviated oxidative damage that occurred under drought stress condition. Therefore, we concluded that salicylic acid and ascorbic acid in the concentration 1 mM have in mitigation of stress caused by drought stress.