Abstract: The effects of aqueous extract of Garcinia kola seed on glucose, superoxide dismutase catalase and malondialdehyde of normal rats were investigated. Oral administration of aqueous seed extract of Garcinia kola at a concentration of 200 mg kg-1 body weight over a period of 21 days, significantly (p<0.05) decreased the levels of blood glucose, increased the activity of superoxide dismutase (p<0.05) and that of malondialdehyde (p<0.05). The treatment however had no significant effect (p>0.05) on the activity of catalase. The elicitation of these effects by the plant is a reflection of its hypoglycemic and antioxidative properties.