Abstract: The antimicrobial properties of various extract of Zingiber officinale (ginger) against Escherichia coli and Pseudomonas aeruginosa that are common causes of gastrointestinal track infection were investigated using the Agar and tube diffusion method. The results obtained revealed that etharolic extract of ginger gave the widest zone of inhibition against one out of the two test organisms at the concentration of 20 mg mL-1. However, Pseudomonas aeruginosa was more sensitive to the extract. It was also observed that the solvent of extraction and its varying concentrations affected the sensitivity of the two test organisms to the plant extract showing that ginger has antimicrobial activities on the test organisms due to its inhibitory effect, thus confirming its use in folk medicine.