Abstract: This study presents data on detection of local risk factors of the main dental disease dental caries by means of express diagnostics methods in children with Down’s syndrome. The task was implemented with the orion-diagnostica diagnostic tool (Finland) that ensures determination of 5 main saliva characteristics and evaluation of dental caries development risk: concentration of Streptococcus mutans, lactobacilli, salivation speed and buffer capacity of saliva (with Dentobuff test strips).