Research Journal of Medical Sciences

Cardioprotective Effects of HMG-Co-A Reductase Inhibitors: Role of the Mechanisms of Preconditioning

Tatyana A. Denysiuk, Lev N. Sernov, Vladimir D. Lutsenko, Oleg U. Shiryaev, Andrey A. Shaposhnikov, Mikhail V. Pokrovsky, Tatyana G. Pokrovskaya, Mikhail V. Korokin and Oleg S. Gudyrev

Abstract: Statins exhibit dose-dependent cardioprotective effect in the simulation of coronary occlusion infarction in rats. In the implementation of cardioprotective effects mechanisms of pharmacological preconditioning have an essential value as evidenced by removal of the effects during blockade of K+-ATP channels with glibenclamide and blockade of iNOS with aminoguanidine.