Abstract: Many people die every day because of heart attack as they have not timely received the medical help. Some suggestions to develop a miniature device implanted in human mouth for day and night monitoring of patient’s saliva structure are represented in this study. The main requirements to the device are indicated. A sensor (for example, implanted in a tooth) periodically takes samples of saliva and analyzes it for the presence of biological markers indicating exacerbation of cardiovascular diseases. The device automatically informs a patient or medical stuff about possible risk. Developing technologies can be used for non-invasive diagnostics of diseases and dysfunctions based on data about biomarkers in the human saliva and provision of early medical intervention.