Abstract: The purpose of this study is comparing temperament and character traits, in patients with coronary heart disease to normal subjects. This is a causal-comparative study. The population include patients referred to SediqehTahereh Rehabilitation Center which among them, 115 patients were selected by convenience sampling. To choose normal people, 115 persons were selected from among all normal people in Isfahan by convenience sampling. The two groups were matched in terms of age, education and gender. Assessment tools are questionnaires of temperament and character. Data were analyzed using software in SPSS18.The results showed a significant difference MANOVA between the two groups in: Components of avoid injury, reward dependence and self-directed. There is not a significant difference in other components. It seems that personality characteristics play an important role in this disorder. To identify and control these variables can help to reduce symptoms of the disease.