Abstract: Neurofibromatosis is a widespread mesodermal dysplasia with protean clinical and radiographic manifestations. This study presented five rare cases of this disorder. Each case was presented in details including radiological examinations. Therapeutic options were investigated and the appropriate choices were administered to patients. These cases are not likely to be highly encountered in routine practice and their reporting helps clinicians not to miss their diagnosis. The present study showed five cases with neurofibromatosis. Some cases showed therapeutic responses while others did not. More studies are encouraged to look for more approaches with therapeutic responses for neurofibromatosis.