Abstract: Antiulcer activity of flowers extract of Nerium indicum was studies in rats in which gastric ulcers were induce by oral administration of indomethacin and pylorus ligation. Flowers extract of Nerium indicum was administered in the dose of 500 and 1000 mg kg-1 orally 30 min prior to ulcer induction. The antiulcer activity was assessed by determining and comparing the ulcer index in the test group with that of the vehicle control group. Gastric total acidity and free acidity were estimated in pylorus ligated rats. Cimetidine was used as a reference drug. The results suggest that methanolic flowers extract of Nerium indicum possesses significant antiulcer activity.