Abstract: Herbal medicine practice has gained acceptance around the globe especially in developing countries because of ease of accessibility, afford-ability, presumed safety and the notion that it is without adverse effect. This is not necessarily true as herbal medicine practices have its own challenges and limitations so Physicians need to know which herb their patients take along with antidiabetic medications as some combinations may be beneficial, harmful or have no effect. In this study, it was summarized the report available on the interaction of herbs and various classes of antidiabetic drugs whether pharmacodynamic (beneficial, harmful or no effect), pharmacokinetic (whether the herb affect absorption, distribution, metabolism or elimination of the drug) and a brief description of the study.