Abstract: The study proves the feasibility of developing a soft medical form of fexofenadine selected composition and developed a rational method of producing fexofenadine gel allows to obtain a drug with high bioavailability and optimum processability. The analyses of physicochemical compatibility of the anti-allergic gel components has been conducted using the Differential Scanning Calorimetry (DSC). The rheological and biopharmaceutical research of soft dosage form of fexofenadine has been conducted.