Abstract: The functional group analysis of various extracts (Hexane, Toluene, Tetrahydrofuran, Aqueous and Methanol) of potential indigenous medicinal plant Andrographis paniculata was recorded. The vibrational assignments, intensities and wave number (cm-1) of dominant peak were obtained from absorption spectra. By this analysis, functional groups such as aminoacids, amides, amines, carboxylic acid, carbonyl compounds, organic hydrocarbons, halogens are present in all the 3 extracts. The present results showed that the crude extracts of this plant having high therapeutic value. In future it is used to treat against various diseases.