Abstract: One of the main subjects with increasing effects in international level is the subject of human rights. Over the years, international evolutions and some challenges resulted from human rights on national sovereignty of states have been observed. In this regard, activities and measures of international organizations and UN in top of them in different fields such as human rights domain have made the principles of national sovereignty more Impressionable than before. Hence, it seems that other traditional perceptions of the concept of national sovereignty are not acceptable in domain of international law in the current age. This is because; such perceptions have lost their credit under effect of evolutions of international law and evidences indicate that the principle of interference in domestic affairs of states has been changed over the time. In this study, effects of human right mechanisms on principle of national sovereignty have been discussed. It should be mentioned that in this study, using scientific analysis method has been considered as a basis.