Abstract: The aim of this study is to find out the effect of learning method, students’ self study and how the interaction of such two variables toward students’ critical thinking skills in economy subject in class X at SMAN 11 Bandung. The study method is quasi experiment by using factorial design 2�3 with participants are all students of class X IIS which consists of 5 classes. Instruments which are used are critical thinking test and self study questionnaire. Data analysis use two-way ANOVA, so study result is obtained that learning method has significant effect towards students’ critical thinking ability, then students’ self study has significant effect toward students’ critical thinking ability and critical thinking ability which has category of self study by using group investigation method show high category of self study whereas critical thinking ability which has self study category by using varied lectures method show medium and low category of self study.