Abstract: Competence is an ability and a skill of a person in the form of knowledge, the ability and skills are required in an office to satisfy the customers and to give motivation in finishing a task. This study aims at determining the relationship of educational competence, work period and training to the performance of ICU and CVCU Nurses at Dr. Wahidin Sudirohusodo Hospital of Makassar. This research applied analytic analysis with cross sectional study. The focus of the research is the ICU and CVCU nurses at Dr. Wahidin Sudirohusodo Hospital of Makassar with 44 respondents. The data is collected through interviews and observations purposively. The result of the research showed that there is a relationship between competence, education, employment and training to the performance. Therefore, it is recommended that structural attention and the improvement is necessary for competence, education, work period and training with the performance.