Abstract: Glycoprotein IIb/ IIIa inhibitors and thienopyridine improve clinical outcomes of patients undergoing primary percutaneus coronary intervention. We present a case of a 74-year-old woman with acute anterior myocardial infarction, treated with primary coronary intervention in whom spontanoeus lingual hematoma was observed after co-administration of tirofiban and clopidogrel. This case emphasizes potentially life-threatening consequence of the clopidogrel and tirofiban co-administration.