Journal of Animal and Veterinary Advances

Year: 2010
Volume: 9
Issue: 5
Page No. 913 - 919

Effects of Medetomidine and Atipamezole on Cerebral Perfusion Pressure in Dogs

Authors : Kazuhito Itamoto, Munekazu Nakaichi, Masaru Okuda, Takeshige Otoi, Hisashi Inokuma and Yasuho Taura

References

Bergstrom, K., 1988. Cardiovascular and pulmonary effects of a new sedative/analgesic (medetomidine) as a preanesthetic drug in the dog. Acta Vet. Scand., 29: 109-116.
PubMed  |  

Bousquet, P., J. Feldman and J. Schwartz, 1984. Central cardiovascular effects of alpha adrenergic drugs: Differences between catecholamines and imidazolines. J. Pharmacol. Exp. Ther., 230: 232-236.
PubMed  |  

Bousquet, P., J. Feldman, R. Bloch and J. Schwartz, 1981. The nucleus reticularis lateralis: A region highly sensitive to clonidine. Eur. J. Pharmacol., 69: 389-392.
PubMed  |  

Busija, D.W. and C.W. Leffler, 1987. Exogenous norepinephrine constricts cerebral arterioles via alpha 2-adrenoceptors in newborn pigs. J. Cereb. Blood. Flow. Metab., 7: 184-188.
PubMed  |  

Doze, V.A., B.X. Chen and M. Maze, 1989. Dexmedetomidine produces a hypnotic-anesthetic action in rats via activation of central alpha-2 adrenoceptors. Anesthesiology, 71: 75-79.
PubMed  |  

Ernsberger, P., R. Guiliano, R.N. Willette and D.J. Reis, 1990. Role of imidazole receptors in the vasodepressor response to clonidine analogs in the rostral ventrolateral medulla. J. Pharmacol. Exp. Ther., 253: 408-418.
PubMed  |  

Favre, J.B., J.P. Gardaz and P. Ravussin, 1995. Effect of clonidine on ICP and on the hemodynamic responses to nociceptive stimuli in patients with brain tumors. J. Neurosurg. Anesthesiol., 7: 159-167.
PubMed  |  

Hayashi, K., R. Nishimura, A. Yamaki, H. Kim, S. Matsunaga, N. Sasaki and A. Takeuchi, 1995. Cardiopulmonary effects of medetomidine, medetomidine-midazolam and medetomidine-midazolam-atipamezole in dogs. J. Vet. Med. Sci., 57: 99-104.
PubMed  |  

Hoffman, W.E., E. Kochs, C. Werner, C. Thomas and R.F. Albrecht, 1991. Dexmedetomidine improves neurologic outcome from incomplete ischemia in the rat. Reversal by the alpha 2-adrenergic antagonist atipamezole. Anesthesiology, 75: 328-332.
PubMed  |  

Hysing, E.S., J.E. Chelly, M.F. Doursout and R.G. Merin, 1992. Comparative effects of halothane, enflurane, and isoflurane at equihypotensive doses on cardiac performance and coronary and renal blood flows in chronically instrumented dogs. Anesthesiology, 76: 979-984.
PubMed  |  

Ishiyama, T., S. Dohi, H. Iida, Y. Watanabe and H. Shimonaka, 1995. Mechanisms of dexmedetomidine-induced cerebrovascular effects in canine in vivo experiments. Anesth Analg., 81: 1208-1215.
PubMed  |  

Itamoto, K., Y. Taura, N. Wada, A. Taga, T. Takuma, H. Matsumura and T. Miyara, 2001. Effect of medetomidine on electroencephalography and use of a quantitative electroencephalograph for evaluating sedation levels in dogs. J. Vet. Med. A Physiol. Pathol. Clin. Med., 48: 525-535.
PubMed  |  

Keegan, R.D., S.A. Greene, R.S. Bagley, M.P. Moore, A.B. Weil and C.E. Short, 1995. Effects of medetomidine administration on intracranial pressure and cardiovascular variables of isoflurane-anesthetized dogs. Am. J. Vet. Res., 56: 193-198.
PubMed  |  

Khan, A., G. Camel and H.M.Jr. Perry, 1970. Clonidine (Catapres): A new antihypertensive agent. Curr. Ther. Res. Clin. Exp., 12: 10-18.
PubMed  |  

Khan, Z.P., C.N. Ferguson and R.M. Jones, 1999. Alpha-2 and imidazoline receptor agonists their pharmacology and therapeutic role. Anaesthesia, 54: 146-165.
CrossRef  |  PubMed  |  Direct Link  |  

Ko, J.C., J.E. Bailey, L.S. Pablo and T.G. Heaton-Jones, 1996. Comparison of sedative and cardiorespiratory effects of medetomidine and medetomidine-butorphanol combination in dogs. Am. J. Vet. Res., 57: 535-540.
PubMed  |  Direct Link  |  

Maze, M., 1989. Anesthesia and ion channel function in the autonomic nervous system. Int. Anesthesiol. Clin., 27: 248-258.
PubMed  |  

McCormick, J.M., P.W. McCormick, J.M. Zabramski and R.F. Spetzler, 1993. Intracranial pressure reduction by a central alpha-2 adrenoreceptor agonist after subarachnoid hemorrhage. Neurosurgery, 32: 974-979.
PubMed  |  

Milne, B., 1991. Alpha-2 agonists and anesthesia. Can. J. Anaesth., 38: 809-813.
PubMed  |  

Muizelaar, J.P. and M.L. Schroder, 1994. Overview of monitoring of cerebral blood flow and metabolism after severe head injury. Can. J. Neurol. Sci., 21: 6-11.
PubMed  |  

Nichols, A.J., J.P. Hieble and R.R. Ruffolo, 1988. The pharmacology of peripheral alpha 1- and alpha 2-adrenoceptors. Rev. Clin. Basic. Pharm., 7: 129-205.
PubMed  |  

Rosner, M.J. and S. Daughton, 1990. Cerebral perfusion pressure management in head injury. J. Trauma., 30: 933-941.
PubMed  |  

Sakaguchi, M., R. Nishimura, N. Sasaki, T. Ishiguro, H. Tamura and A. Takeuchi, 1992. Sedative effects of medetomidine in pigs. J. Vet. Med. Sci., 54: 643-647.
PubMed  |  

Sakakibara, Y., M. Fujiwara and I. Muramatsu, 1982. Pharmacological characterization of the alpha adrenoceptors of the dog basilar artery. Naunyn Schmiedebergs Arch. Pharmacol., 319: 1-7.
PubMed  |  

Scheinin, H., R. Aantaa, M. Anttila, P. Hakola, A. Helminen and S. Karhuvaara, 1998. Reversal of the sedative and sympatholytic effects of dexmedetomidine with a specific alpha2-adrenoceptor antagonist atipamezole: A pharmacodynamic and kinetic study in healthy volunteers. Anesthesiology, 89: 574-584.
PubMed  |  

Sk�rby, T., K.E. Andersson and L. Edvinsson, 1981. Characterization of the postsynaptic alpha-adrenoceptor in isolated feline cerebral arteries. Acta Physiol. Scand., 112: 105-107.
PubMed  |  

Stenberg, D., P. Salven and V.M. Miettinen, 1987. Sedative action of the alpha 2-agonist medetomidine in cats. J. Vet. Pharmacol. Ther., 10: 319-323.
PubMed  |  

Sulek, K.E., 1998. Intracranial Pressure. In: Clinical Neuroanesthesia, Cucchiara, R.F., J.D. Michenfelder and S. Black (Eds.). 2nd Edn., Churchill Livingstone Inc., New York.

Talke, P., C. Tong, H.W. Lee, J. Caldwell, J.C. Eisenach and C.A. Richardson, 1997. Effect of dexmedetomidine on lumbar cerebrospinal fluid pressure in humans. Anesth. Analg., 85: 358-364.
PubMed  |  

Tsukahara, T., T. Taniguchi, H. Usui, S. Miwa, S. Shimohama, M. Fujiwara and H. Handa, 1986. Sympathetic denervation and alpha adrenoceptors in dog cerebral arteries. Naunyn Schmiedebergs Arch. Pharmacol., 334: 436-443.
PubMed  |  

Tsukahara, T., T. Taniguchi, M. Fujiwara and H. Handa, 1983. Characterization of alpha adrenoceptors in pial arteries of the bovine brain. Naunyn-Schmiedeberg`s Arc. Pharmacol., 324: 88-93.
PubMed  |  

Usui, H., M. Fujiwara, T. Tsukahara, T. Taniguchi and K. Kurahashi, 1985. Differences in contractile responses to electrical stimulation and alpha-adrenergic binding sites in isolated cerebral arteries of humans, cows, dogs and monkeys. J. Cardiovasc. Pharmacol., 3: 47-52.
PubMed  |  

Vahe, T.V., 1989. The clinical efficacy of medetomidine. Acta Vet. Scand., 85: 151-153.
PubMed  |  

Vainio, O. and T.V. Vahe, 1990. Reversal of medetomidine sedation by atipamezole in dogs. J. Vet. Pharmacol. Ther., 13: 15-22.
PubMed  |  

Vainio, O., 1990. Reversal of medetomidine-induced cardiovascular and respiratory changes with atipamezole in dogs. Vet, Rec., 127: 447-450.
PubMed  |  

Virtanen, R., 1989. Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet. Scand., 85: 29-37.
PubMed  |  

Virtanen, R., M.J. Savola, V. Saano and L. Nyman, 1988. Characterization of the selectivity, specificity and potency of medetomidine as an alpha 2-adrenoceptor agonist. Eur. J. Pharmacol., 150: 9-14.
PubMed  |  

Zornow, M. H., J.E. Fleischer, M.S. Scheller, K. Nakakimura and J.C. Drummond, 1990. Dexmedetomidine, an alpha 2-adrenergic agonist, decreases cerebral blood flow in the isoflurane-anesthetized dog. Anesth. Analg., 70: 624-630.
PubMed  |  

Zornow, M.H., M.S. Schelle, P.B. Sheehan, M.A. Strnat and M. Matsumoto, 1992. Intracranial pressure effects of dexmedetomidine in rabbits. Anesth. Analg., 75: 232-237.
PubMed  |  

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