References

Abdul, A.B.H., A.S. Al-Zubairi, N.D. Tailan, S.I. Abdel-Wahab, Z.N.M. Zain, S. Ruslay and M.M. Syam, 2008. Anticancer activity of natural compound (Zerumbone) extracted from Zingiber zerumbet in human hela cervical cancer cells. Int. J. Pharmacol., 4: 160-168.
CrossRef  |  Direct Link  |  

Ahmed, R.S., S.G. Suke, V. Seth, A. Chakraborti, A.K. Tripathi and B.D. Banerjee, 2008. Protective effects of dietary ginger (Zingiber officinales Rosc.) on lindane-induced oxidative stress in rats. Phytother. Res., 22: 902-906.
CrossRef  |  Direct Link  |  

Al-Saffar, F.J., S. Ganabadi, S. Fakurazi, H. Yaakub and M. Lip, 2010. Chondroprotective effect of zerumbone on monosodium iodoacetate induced osteoarthritis in rats. J. Applied Sci., 10: 248-260.
CrossRef  |  Direct Link  |  

Altinkaynak, K., H. Suleyman and F. Akcay, 2003. Effect of nimesulide, rofecoxib and celecoxib on gastric tissue glutathione level in rats with indomethacin-induced gastric ulcerations. Polish J. Pharmacol., 55: 645-648.
PubMed  |  

Bastos-Pereira, A.L., D. Lugarini, A. Oliveira-Christoff, T.V. Avila and S. Teixeira et al., 2010. Celecoxib prevents tumor growth in an animal model by a COX-2 independent mechanism. Cancer Chemotherapy Pharmacol., 65: 267-276.
CrossRef  |  

Bove, S.E., S.L. Calcaterra, R.M. Brooker, C.M. Huber and R.E. Guzman et al., 2003. Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis. Osteoarthritis Cartilage, 11: 821-830.
CrossRef  |  

Brunner, L.J., W.M. Bennet and D.R. Koop, 1998. Cyclosporine suppresses rat hepatic cytochrome P450 in a time-dependent manner. Kidney Int., 54: 216-223.
CrossRef  |  

Dabhi, J.K., J.K. Solanki and A. Mehta, 2008. Antiatherosclerotic activity of Ibuprofen, a non-selective COX inhibitor-An animal study. Indian J. Exp. Biol., 46: 476-481.
PubMed  |  

El-Medany, A., A. Mahguoub, A. Mustafa, M. Arafa and M. Morsi, 2005. The effects of selectivecyclooxygenases-2 inhibitors, celecoxib and rofecoxib, on experimental colitis induced by acetic acid in rats. Eur. J. Pharmacol., 507: 291-299.
CrossRef  |  

Fakurazi, S., I. Hairuszah and U. Nanthini, 2008. Moringa oleifera lam prevents acetaminophen induced liver injury through restoration of glutathione level. Food Chem. Toxicol., 46: 2611-2615.
CrossRef  |  Direct Link  |  

Habig, W.H., M.J. Pabst and W.B. Jakoby, 1974. Glutathione S-transferases: The first enzymatic step in mercapturic acid formation. J. Biol. Chem., 249: 7130-7139.
CrossRef  |  PubMed  |  Direct Link  |  

Hayes, A.W., 2008. Principles and Methods of Toxicology. 5th Edn., CRC/Taylor and Francis Group, USA., pp: 2270.

Ibrahim, M.Y., A.B. Abdul, S.I. Abdel Wahab, M.M. Elhassan, A.S. Alzubairi and M.M. Syam, 2009. Attenuation of cisplatin-induced hepatotoxicity in rats using zerumbone. Res. J. Biol. Sci., 4: 777-784.
CrossRef  |  Direct Link  |  

Jusman, S.W.A. and S.A. Halim, 2009. Oxidative stress in liver tissue of rat induced by chronic systemic hypoxia. Makara Kesehatan, 13: 34-38.
Direct Link  |  

Karatopuk, D.U. and A. Gokcimen, 2010. Effect of tenoxicam on rat liver tissue. Turk. J. Gastroenterol., 21: 146-152.
PubMed  |  

Kataria, N., A.K. Kataria, R. Maan and A.K. Gahlot, 2010. Evaluation of oxidative stress in brucella infected cows. J. Stress Physiol. Biochem., 6: 19-25.
Direct Link  |  

Kilty, C., S. Doyle, B. Hassett and F. Manning, 1998. Lutathione S-transferases as biomarkers of organ damage: Applications of rodent and canine GST enzyme immunoassays. Chemico-Biol. Interactions, 111-112: 123-135.
CrossRef  |  

Koul, A., L. Tanwar and N. Arora, 2009. Celecoxib administration exhibits tissue specific effect on ³H-benzo(a)pyrene-DNA adduct formation in cigarette smoke inhaling mice. Indian J. Exp. Biol., 47: 83-90.
Direct Link  |  

Mateos, R., E. Lecumberri, S. Ramos, L. Goya and L. Bravo, 2005. Determination of malondialdehyde (MDA) by high-performance liquid chromatography in serum and liver as a biomarker for oxidative stress: Application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidants from fruits. J. Chromatogr. B, 827: 76-82.
CrossRef  |  Direct Link  |  

Modi, M., M. Mittal and S.J.S. Flora, 2007. Combined administration of selenium and meso-2.3-dimercaptosuccinic acid on arsenic mobilization and tissue oxidative stress in chronic arsenic-exposed male rats. Indian J. Pharmacol., 39: 107-114.

Murakami, A., M. Takahashi, S. Jiwajinda, K. Koshimizu and H. Ohigashi, 1999. Identification of zerumbone in Zingiber zerumbet smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced epstien-barr virus activation. Biosci. Biotechnol. Biochem., 63: 1811-1812.
PubMed  |  

Murakami, A., T. Tanaka, J.Y. Lee, Y.J. Surh and H.W. Kim et al., 2004. Zerumbone, a sesquiterpene in subtropical ginger, suppresses skin tumor initiation and promotion stages in ICR mice. Int. J. Cancer, 110: 481-490.
CrossRef  |  PubMed  |  Direct Link  |  

Nakamura, Y., Y. Chiho, A. Murakami, H. Ohigashi, T. Osawa and K. Uchida, 2004. Zerumbone, a tropical ginger sesquiterpene, activates phase II drug metabolizing enzymes. FEBS Lett., 572: 245-250.
CrossRef  |  PubMed  |  Direct Link  |  

Nelson, D.R., L. Koymans, T. Kamataki, J.J. Stegeman and R. Feyereisen et al., 1996. P450 superfamily: Update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics, 3: 1-42.
Direct Link  |  

Nharet-Somchit, N.M. and M.H. Nur-Shukriah, 2003. Anti-inflammatory property of ethanol and water extracts of Zingiber zerumbet. Indian J. Pharmacol., 35: 181-182.
Direct Link  |  

Ohkawa, H., N. Ohishi and K. Yagi, 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem., 95: 351-358.
CrossRef  |  PubMed  |  Direct Link  |  

Omura, T. and R. Sato, 1964. The carbone monoxide-binding pigment of liver microsomes. J. Biol. Chem., 239: 2370-2378.
PubMed  |  

Park, K., J.H. Yang, Y. Choi, C. Lee, S.Y. Kim and Y. Byun, 2005. Chemoprevention of 4-NQO-induced oral carcinogenesis by co-administration of all-trans retinoic acid loaded microspheres and celecoxib. J. Controlled Release, 104: 167-179.
CrossRef  |  

Pompella, A., A. Visvikis, A. Paolicchi, V. de Tata and A.F. Casini, 2003. The changing faces of glutathione, a cellular protagonist. Biochem. Pharmacol., 66: 1499-1503.
CrossRef  |  Direct Link  |  

Raza, H., A. John, M.S. Lakhani, I. Ahmed and W. Montague, 1998. Multiplicity and tissue specific expression of camel Cytochrome P450(s). Comp. Biochem. Physiol. Part C: Pharmacol. Toxicol. Endocrinol., 121: 205-211.
CrossRef  |  Direct Link  |  

Ruslay, S., F. Abas, K. Shaari, Z.M. Zainal and Maulidiani et al., 2007. Characterization of the components present in the active fractions of health gingers (Curcuma Xanthorrhiza and Zingiber zerumbet by HPLC-DAD ESIMS. Food Chem., 104: 1183-1191.
CrossRef  |  

Sandberg, M., U. Yasar, P. Stromberg, J.O. Hoog and E. Eliasson, 2002. Oxidation of celecoxib by polymorphic cytochrome P450 2C9 and alcohol dehydrogenase. Br. J. Clin. Pharmacol., 54: 423-429.
CrossRef  |  

Sau, A., F.P. Tregno, F. Valentino, G. Federici and A.M. Caccuri, 2010. Glutathione transferases and development of new principles to overcome drug resistance. Arch. Biochem. Biophys., 500: 116-122.
CrossRef  |  Direct Link  |  

Sido, B., V. Hack, A. Hochlehner, H. Lipps, C. Herfarth and W. Droge, 1998. Impairment of intestinal glutathione synthesis in patients with inflammatory bowel disease. Gut, 42: 485-492.
CrossRef  |  

Swarnakar, S., K. Ganguly, P. Kundu, A. Banerjee, P. Maity and A.V. Sharma, 2005. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J. Biol. Chem., 280: 9409-9415.
CrossRef  |  

Szabolcs, A., L. Tiszlavicz, J. Kaszaki, A. Posa and A. Berko et al., 2007. Zerumbone exerts a beneficial effect on inflammatory parameters of cholecystokinin octapeptide-induced experimental pancreatitis but fails to improve histology. Pancreas, 35: 249-255.
CrossRef  |  PubMed  |  Direct Link  |  

Vitcheva, V. and M. Mitcheva, 2007. Changes in liver and brain Cytochrome P450 after multiple cocaine administration, alone and in combination with nifedipine. Arh. Hig. Rada. Toksikol., 58: 287-291.
PubMed  |  

Yang, Y., J.Z. Cheng, S.S. Singhal, M. Saini, U. Pandya, S. Awasthi and Y.C. Awasthi, 2001. Role of glutathione S-transferases in protection against lipid peroxidation: Overexpression of hGSTA2-2 IN K562 cells protects against hydrogen peroxide-induced apoptosis and inhibits Jnk and caspase 3 activation. J. Biol. Chem., 276: 19220-19230.
CrossRef  |  Direct Link  |  

Yee, H.C., Z. Said, N. Hussien, A. Bustaman and N.H. Abdullah, 2006. Screening of chemically synthesized analogues of zerumbone for anti-cancer properties and in vivo investigation of zerumbone in female Balb/C mice with cervical intraepithelial neoplasm (CIN). BSc. Thesis, University of Putra, Malaysia

Zhu, H.Z., X.L. Zhang and Y.S. Chen, 1998. Expression of glutathione S-transferase placental mRNA in hepatic preneoplastic lesions in rats. World J. Gastroenterol., 4: 38-40.
PubMed  |  Direct Link  |