Journal of Animal and Veterinary Advances

Year: 2014
Volume: 13
Issue: 15
Page No. 937 - 944

Immunotoxic Action of Aflatoxin B1 Against Lymphoid Organs is Coupled with the High Expression of Bcl-2 by Reticulo-Epithelial Cells in Broiler Chickens

Authors : Carmen Solcan, Gheorghe Solcan, Bogdan Oprisan, Mihaela Spataru, Constantin Spataru and Viorel Floristean

References

Anderson, G. and Y. Takahama, 2012. Thymic epithelial cells: Working class heroes for T cell development and repertoire selection. Trends Immunol., 33: 256-263.
CrossRef  |  Direct Link  |  

Assaf, H., H. Azouri and M. Pallardy, 2004. Ochratoxin A induces apoptosis in human lymphocytes through down regulation of Bcl-xL. Toxicol. Sci., 79: 335-344.
CrossRef  |  

Bokhari, A., A. Qayyum, A. Saeed, M.H. Raza and M.S. Shahzad et al., 2003. Effect of aflatoxin B1 on different body tissues of Gallus domesticus. J. Anim. Vet. Adv., 2: 76-78.
Direct Link  |  

Brahmi, D., C. Bouaziz, Y. Ayed, H. Ben Mansour, L. Zourgui and H. Bacha, 2011. Chemopreventive effect of cactus Opuntia ficus indica on oxidative stress and genotoxicity of aflatoxin B1. Nutr. Metab., Vol. 8. 10.1186/1743-7075-8-73

Celik, I., H. Oguz, O. Demet, H.H. Donmez, M. Boydak and E. Sur, 2000. Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers. Br. Poult. Sci., 41: 430-439.
CrossRef  |  PubMed  |  Direct Link  |  

Chen, F.F., J.J. Yan, Y.T. Jin and I.J. Su, 1996. Detection of Bcl-2 and p53 in thymoma: Expression of Bcl-2 as a reliable marker of tumor aggressiveness. Hum. Pathol., 27: 1089-1092.
CrossRef  |  Direct Link  |  

Cheng, E.H., D.G. Kirsch, R.J. Clem, R. Ravi and M.B. Kastan et al., 1997. Conversion of Bcl-2 to a Bax-like death effector by caspases. Science, 278: 1966-1968.
PubMed  |  

Cimmino, A., G.A. Calin, M. Fabbri, M.V. Iorio and M. Ferracin et al., 2005. MiR15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. USA., 102: 13944-13949.
CrossRef  |  

De Meis, J., D.A. Farias-de-Oliveira, P.H.N. Panzenhagen, N. Maran, D.M.S. Villa-Verde, A. Morrot and W. Savino, 2012. Thymus atrophy and double-positive escape are common features in infectious diseases. J. Parasitol. Res., 10.1155/2012/574020

Eguchi, Y., D.L. Ewert and Y. Tsujimoto, 1992. Isolation and characterization of the chicken Bcl-2 gene: expression in a variety of tissues including lymphoid and neuronal organs in adult and embryo. Nucleic Acids Res., 20: 4187-4192.
PubMed  |  

Ehrich, M., M. Acha and C. Larsen, 1988. Interactions of aflatoxin and the antioxidant butylated hydroxytoluene in two-week-old chicks. Vet. Res. Commun., 12: 329-333.
CrossRef  |  Direct Link  |  

Engel, P., D. Francis and N. Graem, 1998. Expression of bcl‐2 in fetal thymus, thymomas and thymic carcinomas. APMIS, 106: 449-455.
CrossRef  |  Direct Link  |  

Gao, M., C.M. Lola, M. Wang, K.D. Miller, G.W. Sledge, G.D. Hutchins and Q.H. Zheng, 2010. Synthesis of carbon-11-labeled tricyclic necroptosis inhibitors as new potential PET agents for imaging of tumor necrosis factor α (TNF-α). Applied Radiat. Isot., 68: 1950-1958.
CrossRef  |  Direct Link  |  

Hiroshima, K., A. Iyoda, T. Toyozaki, Y. Supriatna and K. Shibuya et al., 2002. Proliferative activity and apoptosis in thymic epithelial neoplasms. Mod. Pathol., 15: 1326-1332.
Direct Link  |  

Hockenbery, D.M., M. Zutter, W. Hickey, M. Nahm and S.J. Korsmeyer, 1991. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA., 88: 6961-6965.
Direct Link  |  

Huang, S.T.J. and J.A. Cidlowski, 2002. Phosphorylation status modulates Bcl-2 function during glucocorticoid-induced apoptosis in T lymphocytes. FASEB J., 16: 825-832.
CrossRef  |  Direct Link  |  

Hussain, Z., M.Z. Khan and Z.U. Hassan, 2008. Production of aflatoxins from Aspergillus flavus and acute aflatoxicosis in young broiler chicks. Pak. J. Agric. Sci., 45: 95-102.

Jacotot, E., K.F. Ferri and G. Kroemer, 2000. Apoptosis and cell cycle: Distinct checkpoints with overlapping upstream control. Pathol. Biol. (Paris), 48: 271-279.
PubMed  |  

Jakhar, K.K. and J.R. Sadana, 2004. Sequential pathology of experimental aflatoxicosis in quail and the effect of selenium supplementation in modifying the disease process. Mycopathologia, 157: 99-109.
CrossRef  |  Direct Link  |  

Kumar, R. and C. Balachandran, 2009. Histopathological changes in broiler chickens fed aflatoxin and cyclopiazonic acid. Veterinarski Arhiv, 79: 31-40.
Direct Link  |  

Kusumaningtyas, E., R. Widiastuti and R. Maryam, 2006. Reduction of aflatoxin B1 in chicken feed by using Saccharomyces cerevisiae, Rhizopus oligosporus and their combination. Mycopathologia, 162: 307-311.
CrossRef  |  Direct Link  |  

Li, D., Y. Cao, L. He, N. Wang and J.R. Gu, 1993. Aberrations of p53 gene in human hepatocellular carcinoma from China. Carcinogenesis, 14: 169-173.
CrossRef  |  PubMed  |  

Marino, M. and H. Muller-Hermelink, 1985. Thymoma and thymic carcinoma. Relation of thymoma epithelial cells to the cortical and medullary differentiation of thymus. Virchows. Arch. A Pathol. Anat. Histopathol., 407: 119-149.
PubMed  |  

Methenitou, G., C. Maravelias, S. Athanaselis, A. Dona and A. Koutselinis, 2001. Immunomodulative effects of aflatoxins and selenium on human natural killer cells. Vet. Hum. Toxicol., 43: 232-234.
PubMed  |  

Michael, G.Y., P. Thaxton and P.B. Hamilton, 1973. Impairment of the reticuloendothelial system of chickens during aflatoxicosis. Poult. Sci., 52: 1206-1207.
CrossRef  |  Direct Link  |  

Oguz, H. and V. Kurtoglu, 2000. Effect of clinoptilolite on performance of broiler chickens during experimental aflatoxicosis. Br. Poult. Sci., 41: 512-517.
CrossRef  |  Direct Link  |  

Ortatatli, M., H. Oguz, F. Hatipoglu and M. Karaman, 2005. Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure. Res. Vet. Sci., 78: 61-68.
CrossRef  |  

Parlata, S.S., M. Ozcanb and H. Oguzc, 2001. Biological suppression of aflatoxicosis in Japanese quail (Coturnix coturnix japonica) by dietary addition of yeast (Saccharomyces cerevisiae). Res. Vet. Sci., 71: 207-211.
CrossRef  |  Direct Link  |  

Poliani, P.L., W. Vermi and F. Facchetti, 2009. Thymus microenvironment in human primary immunodeficiency diseases. Curr. Opin. Allergy Clin. Immunol., 9: 489-495.
CrossRef  |  PubMed  |  

Richard, J.L., 1991. Mycotoxins as Immunomodulators in Animal Systems. In: Mycotoxins, Cancer and Health, Bray, G.A. and D.H. Ryan (Eds.). Louisiana State University Press, Baton Rouge, Louisiana, USA., pp: 197-220.

Rincheval, V., M. Bergeaud, L. Mathieu, J. Leroy and A. Guillaume et al., 2012. Differential effects of Bcl-2 and caspases on mitochondrial permeabilization during endogenous or exogenous reactive oxygen species-induced cell death. Cell Biol. Toxicol., 28: 239-253.
CrossRef  |  PubMed  |  

Robens, J.F. and J.L. Richard, 1992. Aflatoxins in animal and human health. Rev. Environ. Contam. Toxicol., 127: 69-94.
PubMed  |  Direct Link  |  

Savino, W., 2006. The thymus is a common target organ in infectious diseases. PLoS Pathog., Vol. 2. 10.1371/journal.ppat.0020062

Stern, M.C., D.M. Umbach, C.Y. Mimi, S.J. London, Z.Q. Zhang and J.A. Taylor, 2001. Hepatitis B, aflatoxin B1 and p53 codon 249 mutation in hepatocellular carcinomas from Guangxi, People's Republic of China and a meta-analysis of existing studies. Cancer Epidemiol. Biomarkers Prev., 10: 617-625.
Direct Link  |  

Strasser, A., A.W. Harris, M.L. Bath and S. Cory, 1990. Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature, 348: 331-333.
CrossRef  |  Direct Link  |  

Sur, E. and I. Celik, 2003. Effects of aflatoxin B1 on the development of the bursa of Fabricius and blood lymphocyte acid phosphatase of the chicken. Br. Poult. Sci., 44: 558-566.
CrossRef  |  Direct Link  |  

Thaxton, J.P., H.T. Tung and P.B. Hamilton, 1974. Immunosuppression in chickens by aflatoxin. Poult. Sci., 53: 721-725.
CrossRef  |  Direct Link  |  

Tsujimoto, Y., J. Gorham, J. Cossman, E. Jaffe and C.M. Croce, 1985. The t (14; 18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science, 229: 1390-1393.
CrossRef  |  Direct Link  |  

Vaux, D.L., S. Cory and J.M. Adams, 1988. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature, 335: 440-442.
CrossRef  |  PubMed  |  

Verma, J., T.S. Johri, B.K. Swain and S. Ameena, 2004. Effect of graded levels of aflatoxin, ochratoxin and their combinations on the performance and immune response of broilers. Br. Poult. Sci., 45: 512-518.
CrossRef  |  PubMed  |  Direct Link  |  

Vermeulen, K., Z.N. Berneman and D.R. Van Bockstaele, 2003. Cell cycle and apoptosis. Cell Proliferation, 36: 165-175.
CrossRef  |  Direct Link  |  

Wang, F., G. Shu, X. Peng, J. Fang and K. Chen et al., 2013. Protective effects of sodium selenite against aflatoxin B1-induced oxidative stress and apoptosis in broiler spleen. Int. J. Environ. Res. Public Health, 10: 2834-2844.
CrossRef  |  Direct Link  |  

Wang, Z.H., M.X. Ding, S.B. Chew-Cheng, J.P. Yun and E.C. Chew, 1998. Bcl-2 and Bax proteins are nuclear matrix associated proteins. Anticancer Res., 19: 5445-5449.
PubMed  |  

Wangikar, P.B., P. Dwivedi, N. Sinha, A.K. Sharma and A.G. Telang, 2005. Teratogenic effects in rabbits of simultaneous exposure to ochratoxin A and aflatoxin B1 with special reference to microscopic effects. Toxicololgy, 215: 37-47.
CrossRef  |  Direct Link  |  

Wild, C.P. and P.C. Turner, 2002. The toxicology of aflatoxins as a basis for public health decisions. Mutagenesis, 17: 471-481.
CrossRef  |  Direct Link  |  

Wild, C.P., F. Yin, P.C. Turner, I. Chemin and B. Chapot et al., 2000. Environmental and genetic determinants of aflatoxin-albumin adducts in the Gambia. Int. J. Cancer, 86: 1-7.
CrossRef  |  Direct Link  |  

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