Abstract: The main objective of this study was to compare two vaccines against infectious bursal disease in broiler chicken with maternally derived antibody. One hundred and sixty eight, 1 day old broiler chickens (ISA 57) were randomly assigned to seven groups, namely; 1, 2 and 3 (V1 (1), V1 (10) V1 (10)) vaccinated Subcutaneously (SC) with D78 IBDV (Intervet) and 4, 5 and 6 V2 (1), V2 (10) V2 (18) vaccinated with transmune vaccine (Ceva) at 1, 10 and 18 days while group 7 were kept as Control (C). All chickens were bled weekly for 49 days post-vaccination for antibody titration using ELISA test. Body weight and thymus, bursa and spleen ratios scores were determined at 21 and 42 days while RNA was extracted from these tissues and run for virus detection studies. The result reveled non-significant differences between groups V1 (1), V1 (10) V2 (1) and V2 (10) in body weight. However, body weight in groups V1 (18) and V2 (18) were significantly different from all other groups at day 21. At 42 days, group V2 (10) was significantly different compared with other groups. However, groups V1 (1), V1 (10) V2 (1) and V2 significantly differed from controls. Antibody titers against NDV were not significantly different in all groups except in the 7th week of the experiment. However, antibody titers against IBDV differed significantly at 4, 5 and 7 weeks post-vaccination in birds vaccinated at day old. Similar results were recorded in 3, 4 and 5 weeks post-vaccination. It is concluded that both vaccines induce an adequate response in performance at 1, 10 and 18 days and both vaccines responded well at the end of the experiment. However, transmune vaccine has been showed significant antibody titers against IBDV in the chickens vaccinated at 18 days old.