Abstract: Systems of progressiveness of gliomatous cells involving transformation of proliferative to infiltrative tumor cell activity primarily involving neuropil would in various ways perhaps be indicative of also systems of angiogenesis of autocrine nature. Certainly, considerations of how paracrine effect evolves as autocrine effect and also of how autocrine effect is itself a consequence of groups of active paracrine influence would perhaps implicate the individual gliomatous cell as a paradoxical grouping of such individual gliomatous cells to constitute aggregate phenomena within a truly integral gliomatous lesion. Indeed, in terms of an integral glioma made up of strictly individually proliferating and infiltrating gliomatous cells one would have to additionally consider how paracrine effect might both evolve to autocrine mechanistic pathways and conversely how autocrine systems might also evolve in their turn to mechanistic pathways of paracrine effect. In simple terms, indeed, infiltrativeness of individual tumor cells would be simply an autocrine and paracrine trophic expression of how such individual gliomatous cells would evolve as a single integral gliomatous lesion in that individual patient.