Abstract: Neurodegeneration constitutes a loss of neuronal cells in terms of ongoing injury to cell membranes and organelles. A loss of membranous constituents of the cell appears to account for a process of cerebral cortical atrophy consistent with a further injury to nuclei in the form of DNA fragmentation and induced apoptosis. One might recognize the development of neurofilament aggregation and of beta-amyloid fibrillogenesis in terms of a selective involvement of the neuronal cell body in the neurodegeneration. Alzheimer`s disease constitutes a representation of onset dynamics with aging of the central nervous system in the ongoing continuum of further injury to the neuronal cell. A spectrum of dynamic changes would involve in particular a targeting of autophosphorylation systems based on membranes and constituting synaptic injury as a primary site of action. Synapses and cell organelles are a constituent system of dynamic turnover particularly susceptible to ongoing injury as represented and as further developed by such systems as protein molecular misfolding and oxidative stress, within an overall context of cytokine and chemokine action.