Authors : Lawrence M. Agius
Abstract: A metastatic cascade appears to operate as a non-random predetermined system of selective advantage implicating initially a sieving effect by the first capillary beds in an organ of spread. A seed-soil predilection appears to constitute a released system of promotion enhancing progression of tumor cell proliferation as a critical step in the metastatic cascade. One might redefine events in terms of promotion of pathways influencing subsequent acquisition of attributes. Permeation and embolic spread via vessels would constitute a realized idealization of events primarily characterized in terms of ongoing changes in phenotype of tumor cells both as genetically unstable cells and as increasingly self-progressive pathways of strictly sequential type.
Lawrence M. Agius , 2006. Dynamics of Metastasis of Breast Carcinoma to Brain. International Journal of Molecular Medicine and Advance Sciences, 2: 292-298.