Authors : Neha Shekhawat and Rekha Vijayvergia
Abstract: The crude methanolic extract of Madhuca indica (Sapotaceae) at 50, 100 and 200 mg kg-1 body weight were evaluated for anti-inflammatory, analgesic and antipyretic activities in male wistar rats. Anti-inflammatory activity was studied by using carrageenan induced oedema right hind paw volume while the analgesic effect was evaluated using acetic acid-induced abdominal pains i.e., nociception response. The brewer’s yeast-induced pyrexia model was used for antipyretic investigation. Phytochemical screening of the alcoholic extract revealed the presence of tannins, flavonoids, steroids, terpenes, cardiac glycosides and saponins. The extract at all the doses used and the indomethacin significantly inhibited carrageenan induced inflammation in a manner that was not dose dependent. The extract reduced the acetic acid induced pain licking. While the 50 and 100 mg kg-1 body weight of the extract reduced the brewer’s yeast provoked elevated body temperature in rats after 60 min that of 200 mg kg-1 body weight manifested from 30 min. The results suggest a potential benefit of M. indica methanolic extract in treating conditions associated with inflammation, pain and fever. These properties might be adduced to the presence of the phytoconstituents.
Neha Shekhawat and Rekha Vijayvergia, 2010. Investigation of Anti-Inflammatory, Analgesic and Antipyretic Properties of Madhuca indica GMEL. International Journal of Molecular Medicine and Advance Sciences, 6: 26-30.