Authors : Satarupa Mohanty, Rohan Chauhan and Biswajit Sahoo
Abstract: Analysis of motif in DNA sequences are growing into a significant context in the domain of gene regulation and in the same way, identification of motif is a most crucial issue in the study of computational biology. This study addresses the issues of motif search in biological DNA sequences using an evolutionary approach. The experiment is conducted using the Genetic algorithm framework along with a novel approach of generation of a highly fit population of solutions and then converging to optimal motif using secondary fitness function. The proposed model calculate the average value of given sequences and then iterate to generate the optimum population as the strings those are closer to the average value in order to achieve a better rate of convergence to the optimum motif. The experimental study on simulated data using evolutionary approach is recorded and proofs its consistency.
Satarupa Mohanty, Rohan Chauhan and Biswajit Sahoo, 2018. Genetic Algorithm for Planted Motif Search (l, d) with Iteration on Average Value. International Journal of Soft Computing, 13: 18-24.