Authors : M. M. Rahman , Zahed U. M. Khan and S.M. H. Rashid
Abstract: An inactivated Salmonella vaccine was prepared from 5 x 107 cells of Salmonella gallinarum to assess the potential protective efficacy of Salmonella gallinarum vaccine. Specific pathogen free(SPF) hens were vaccinated at 6 weeks and 10 weeks of age and challenged orally at 14 weeks of age with 107 cells of homologous Salmonella gallinarum strain. The nonvaccinated chickens were also challenged with same number of Salmonella gallinarum cells. The antibody titers of the vaccinated hens were detected by rapid serum plate agglutination test(RSPAT) and tube agglutination test. Non-vaccinated hens were observed for 28 days for their changes. Rapid serum plate agglutination test and tube agglutination test revealed that the antibody titers of vaccinated hens rose quickly reaching peak at 8th week post vaccination and were still high at 12th week post vaccination. After challenge, antibody titers were also high and were gradually decreasing upto 20 weeks post vaccination. No antibody titer was detected in non-vaccinated control group.
M. M. Rahman , Zahed U. M. Khan and S.M. H. Rashid , 2005. Evaluation of the Efficacy of a Bacterin Against Salmonella gallinarum Infection . Journal of Animal and Veterinary Advances, 4: 332-334.